Possible involvement of downregulation of the apelin – APJ system in 1 doxorubicin - induced cardiotoxicity 2
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چکیده
Possible involvement of downregulation of the apelin–APJ system in 1 doxorubicin-induced cardiotoxicity 2 Juri Hamada , Altansarnai Baasanjav, Natsumi Ono, Kazuya Murata, Koichiro 3 Kako, Junji Ishida , Akiyoshi Fukamizu 2 4 Graduate School of Life and Environmental Sciences, Life Science Center, 5 Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 6 Tennodai, Tsukuba, Ibaraki 305-8577, Japan 7 Running Head—Effects of APJ gene deletion on Dox-induced carditoxicity 8 Keywords—apelin, APJ, doxorubicin, cardiotoxicity 9 To whom correspondence should be addressed. 10 Akiyoshi Fukamizu, Ph. D 11 Life Science Center, Tsukuba Advanced Research Alliance (TARA), 12 Graduate School of Life and Environmental Sciences, 13 University of Tsukuba, 14 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan. 15 Tel/Fax: 81-298-53-6070 16 17 Articles in PresS. Am J Physiol Heart Circ Physiol (February 13, 2015). doi:10.1152/ajpheart.00703.2013
منابع مشابه
Possible involvement of downregulation of the apelin-APJ system in doxorubicin-induced cardiotoxicity.
Apelin peptide is an endogenous ligand of APJ (a putative receptor protein related to the angiotensin II type 1 receptor), which is a member of a G protein-coupled receptor superfamily with seven transmembrane domains. Recent findings have suggested that the apelin-APJ system plays a potential role in cardiac contraction and cardioprotection. In the present study, we show that the apelin-APJ sy...
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